Effects of the movement of insertion sequences on the structure of VanA glycopeptide resistance elements in Enterococcus faecium.
نویسندگان
چکیده
A Tn1546-related element with IS1216V at position 8839 underwent a structural change after storage of the host strain of Enterococcus faecium at 4 degrees C. The element acquired IS1542 at position 3932, nucleotides 8732 to 8831 were deleted, and the first 3417 nucleotides were lost and replaced by an inverted copy of the IS1216V-vanY-vanZ-inverted-repeat block from the 3' end. Insertion sequence movement is likely to play a key role in the evolution of VanA resistance elements.
منابع مشابه
Disruption of vanS by IS1216V in a clinical isolate of Enterococcus faecium with VanA glycopeptide resistance.
The elements that mediate VanA glycopeptide resistance in enterococci are heterogeneous. Twenty-four distinct VanA elements were identified among a collection of enterococci isolated from hospital patients and nonhuman sources in the United Kingdom (9). Despite their diversity, all these elements showed extensive homology with the prototype VanA transposon, Tn1546, from Enterococcus faecium BM4...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 44 5 شماره
صفحات -
تاریخ انتشار 2000